In silico potential vaccine against hps06257 in Haemophilus parasuis serovar 5
- takbook
- پزشکی عمومی
- 14th سپتامبر 2016
- بدون نظر
In silico potential vaccine against hps06257 in Haemophilus parasuis serovar 5
Haemophilus parasuis is a small, pleomorphic, NAD-dependent member of the family Pasteurellaceae. This bacterium is the etiological agent of Glässer’s disease in swine, which is characterized by polyserositis and arthritis. Once a sporadic disease, it has increased in prevalence and severity in recent years with the adoption of new production technologies which has led to pigs being susceptible to this infection. However, a lack of protective cross-immunity against some strains and partial cross-protection among serotypes has been reported [4,5], pointing to the difficulty in identifying protective immunogens for a universal vaccine. Initial studies have already shown the importance of circulating antibodies in controlling H. parasuis infection. After experimental infection in…
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