{"id":28754,"date":"2016-09-16T08:51:19","date_gmt":"2016-09-16T08:51:19","guid":{"rendered":"http:\/\/www.takbook.com\/best\/substitution-effects-on-stability-and-activation-energies-for-producing-3-alkyl-8-substituted-3h-imidazo45-aacridine-11-carbonitrileas-pharmaceut\/"},"modified":"2016-09-16T08:51:19","modified_gmt":"2016-09-16T08:51:19","slug":"substitution-effects-on-stability-and-activation-energies-for-producing-3-alkyl-8-substituted-3h-imidazo45-aacridine-11-carbonitrileas-pharmaceut","status":"publish","type":"post","link":"https:\/\/www.takbook.com\/best\/substitution-effects-on-stability-and-activation-energies-for-producing-3-alkyl-8-substituted-3h-imidazo45-aacridine-11-carbonitrileas-pharmaceut\/","title":{"rendered":"Substitution effects\u2019 on stability and activation energies for producing 3-alkyl-8-substituted-3H-imidazo[4,5-a]acridine- 11-carbonitrileas pharmaceut"},"content":{"rendered":"<div style=\"text-align:center;direction:rtl\">\n<div style=\"border:1px solid #000000!important;padding:12px!important;overflow:auto!important;background:#ffffff!important;margin-bottom:10px;min-width:300px!important;max-width:500px!important;\"><a href=\"http:\/\/par3.4kia.ir\/info\/37698\/i\/?getppsid=18004\" target=\"_blank\" rel=\"nofollow\"><img src=\"http:\/\/www.takbook.com\/best\/wp-content\/uploads\/2016\/09\/14747_1468126016-1.jpg\" alt=\"Substitution effects\u2019 on stability and activation energies for producing 3-alkyl-8-substituted-3H-imidazo[4,5-a]acridine- 11-carbonitrileas pharmaceut\" style=\"float:right !important;margin:0 !important;margin-left:10px !important;padding-top:10px !important;width:130px;height:125px;\" \/><\/a><\/p>\n<h3 style=\"font:bold 14px\/1.7 Tahoma!important;margin-top:0px!important;\"><a href=\"http:\/\/par3.4kia.ir\/info\/37698\/i\/?getppsid=18004\" target=\"_blank\" style=\"text-decoration:none!important;color:#195ada!important;\" rel=\"nofollow\">Substitution effects\u2019 on stability and activation energies for producing 3-alkyl-8-substituted-3H-imidazo[4,5-a]acridine- 11-carbonitrileas pharmaceut<\/a><\/h3>\n<p style=\"font:200 13px\/1.5 Tahoma!important;text-align:justify!important;direction:rtl!important;color:#000000\">In this paper, the effect of substitutions in positions3 and 8 in the producing of 3-alkyl-8substituted-3H-imidazo[4,5-a]acridine-11-carbonitrile as pharmaceutical compounds, based onthe valuable thermodynamic and kinetic information, employing DFT(Density FunctionalTheory) study and PCM model (polarizable continuum) for considering solvent effects, havebeen fully investigated.In additional, calculations in the gas phase, substitution effects and stability of all species inmethanol were discussed completely.The effect of methanol as a polar solvent reduced the activation energy for the final step (losingH2O) and first step (tautomerization), while increased Eact in the cyclization step, although allspecies are more stable in solution phase.Based on theoretical calculations the final step&#8230;<\/p>\n<div style=\"text-align:center\"><a href=\"http:\/\/par3.4kia.ir\/info\/37698\/i\/?getppsid=18004\" target=\"_blank\" style=\"background-color:#195ada!important;color:#ffffff!important;text-decoration:none!important;font-size:20px!important;font-weight:bold!important;padding:6px 10px;font-family:arial;\" rel=\"nofollow\">\u062c\u0632\u0626\u06cc\u0627\u062a \u0628\u06cc\u0634\u062a\u0631 \/ \u062f\u0627\u0646\u0644\u0648\u062f<\/a><\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Substitution effects\u2019 on stability and activation energies for producing 3-alkyl-8-substituted-3H-imidazo[4,5-a]acridine- 11-carbonitrileas pharmaceut In this paper, the effect of substitutions in positions3 and 8 in the producing of 3-alkyl-8substituted-3H-imidazo[4,5-a]acridine-11-carbonitrile as pharmaceutical [&#8230;]<\/p>\n","protected":false},"author":1,"featured_media":28755,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"amp_status":""},"categories":[1105],"tags":[1352,9269,2509,4019],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v14.9 - 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